Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity
نویسندگان
چکیده
منابع مشابه
Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity
Natural killer (NK) cells are essential for killing transformed and virally infected cells. To prevent auto-reactivity, NK cell activation is inhibited by inhibitory receptors that activate the tyrosine phosphatase SHP-1, which dephosphorylates signaling molecules crucial for NK cell activation. Initially, only a single SHP-1 substrate was identified in NK cells, the GEF VAV1. We recently demon...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2016
ISSN: 1942-0889
DOI: 10.1080/19420889.2016.1216739